Blogs
Deisseroth Lab explores link between cardiac physiology and emotional states
Figure from the recent Deisseroth Lab article in Nature: d, Electrode tracks from n = 5 mice (3 ChRmine and 2 control) over 60 recording sessions co-registered to the common Allen Brain Atlas. e, Locations of recorded single units overlaid onto the Allen Brain Atlas....
Use gaming controllers with the MPM System
The upcoming Pathfinder software release for the Multi-Probe Micromanipulator (MPM) System contains a number of features and enhancements* suggested by our users. One such feature is support for Xbox-style gaming controllers (wired, or with Bluetooth or USB wireless...
MPM System supports research into cellular-level mechanisms underlying brain function
Researchers at the Deisseroth Lab at Stanford University use the MPM Multi-Probe Micromanipulator for in-vivo electrophysiology with optogenetic stimulation. They published results in an article, “Cell-type-specific population dynamics of diverse reward computations,”...
Allen Institute shares protocol for inserting multiple probes in awake, head-fixed mice
Allen Brain Observatory Neuropixels recording rig, from the paper in Nature Protocols. The label “f” indicates one of the six three-axis New Scale manipulators in the rig. As the creator and supplier of the Multi-Probe Manipulator System (MPM), we often are asked to...
Slow insertion of silicon probes improves neural recording quality
A paper provides convincing evidence for the benefits of inserting silicon probes slowly into the brain for acute neural recording. The New Scale MPM Multi-Probe Micromanipulator System enables slow, smooth, and fully programmable insertion speeds.
Big Science. Big Data. Big Discoveries.
NEUROSCIENCE 2022 WRAP-UP By David Henderson, CEO It was great to be in-person for Neuroscience 2022, and to see first-hand the amazing work being done by our partners and customers around the world. The MPM Micro-Manipulator System was shown at four booths: New Scale...
Resolution, repeatability, and accuracy in micro motion systems
In this video we review the basic definitions of resolution, accuracy, and repeatability. These parameters fundamentally impact the complexity, cost, and development time of a motion system. Understanding them can help you meet your requirements for performance,...
MPM System: Pathfinder Software with trajectory planning and data acquisition apps
NEUROSCIENCE 2022 SNEAK PREVIEW – MPM PATHFINDER The integration of the MPM Multi-Probe Micromanipulator System’s Pathfinder Software with trajectory planning and data acquisition apps with will allow you to simulate, plan, execute, debug and repeat your...
Optogenetics: Lighting up the brain enables surprising discoveries
Image credit: Laser Focus World / Travis Babola A recent article in Laser Focus World explains the basics of optogenetics and describes newer techniques, like single-cell and holographic optogenetics, that allow neuroscientists to give every cell its own code and to...
Neural Probe Trajectory Planning and Automated Insertion
Obtaining successful in-vivo electrophysiological recordings with silicon neural probes requires a set of carefully executed activities which include: Careful planning of the optimum insertion path. Accurate placement of the probe to enter the brain at the designated...
Using Probe Mount 1AS and Alignment Fixture with Neuropixels 1.0 Probes
By clamping as far back from the probe shank as possible, the MPM Probe Mount 1As allows researchers to maximize the density of probes in multi-probe neural recording experiments. Mount Maximizes Density of Neuropixels 1.0 Probes in Multi-Probe Recording New Scale’s...See the MPM System live at the Allen Institute
New Scale Technologies’ micro-manipulators at the Allen Institute (photos by the Allen Institute) Are you interested in learning about multi-probe experimental techniques with Neuropixels probes… from the experts in extracellular electrophysiology recording?...
Optogenetics and the Multi-Probe Micromanipulator
Optogenetics has progressed rapidly from its beginnings in 2005, thanks in part to advances in supporting fields including photonics and micro-mechatronics. The MPM Micromanipulator is unique in its ability to simultaneously position multiple silicon probes and optical fibers for optogenetics.
SPIE publication explores photonics and the brain
The Jan/Feb 2022 issue of Photonics Focus, a publication of the international society for optics and photonics (SPIE), examines multiple perspectives on photonics and the brain. Several articles suggest future applications for silicon probes, beyond their current use...Video: M3-LS Linear Smart Stage Applications
Embedded motion for spectroscopy, microscopy and manipulation This video demonstrates a variety of applications using M3-LS Linear Smart Stages to embed compact, closed-loop linear motion. This smart micro stage puts very precise motion in the palm of your hand so you...
Multi-Probe Micromanipulator helps researchers explore fMRI connectivity
An article in Nature Communications describes how researchers in Italy combined neural manipulations, resting-state fMRI and in vivo electrophysiology (using the New Scale MPM Multi-Probe Micromanipulator) to probe how inactivation of a cortical node causally affects brain-wide fMRI coupling in the mouse.
New White Paper: Embedded Motion Solves Extended Reality (XR) Challenges
New Scale Technologies has released a new white paper describing the use of M3 Smart Modules – or “embedded micro motion devices” – in systems for extended reality (XR) applications. Embedded micro motion devices are solving challenges that are...
Embedded Motion Speeds Development of New NGS Instruments for DNA Sequencing
To achieve the goals of higher throughput and lower costs, NGS instrument developers are using smaller samples, parallel sequencing, and more automation. These factors necessitate miniaturization and distributed control of the photonics subsystems used in DNA sequencing instruments.
