Neuroscience Blog
Updates on what’s happening in the world of micropositioning for neuroscience research.
Live Demo: 4-Shank Probe Trajectory Planning | Pathfinder, Pinpoint & NTE
See how to plan trajectories and insert multiple 4-shank silicon probes, viewing real-time positions in the Allen CCF with Pinpoint & NTE. About this presentation: The latest releases of Neuropixels Trajectory Explorer (NTE), Pinpoint, and New Scale’s...
Upright Magnetic Arms, with Extender Posts, Improves 4DOF Multi-Probe Micromanipulator Flexibility
By Ed Friedrich Many of our Multi-Probe Micromanipulator users look to us for guidance on how to optimize their Multi-Probe Micromanipulator (MPM) configuration for their lab and research goals. Our answer is usually “it depends” – what does the behavioral apparatus...
Improvements to the Multi-Probe Micromanipulator System
By Ed Friedrich We love hearing from our customers, and we truly listen to constructive feedback and opportunities for improvement. Over the past year, we have been thrilled with the progress MPM users have made with our ambitious Pathfinder Software initiative,...
More Probes. Less Planning. More Accuracy. Neuroscience 2023!
NEUROSCIENCE 2023 WRAP-UP By Stefan Friedrich My favorite trade show of the year quickly came and went. Each year at SfN’s Neuroscience show, we’re struck by the incredible research being done by our customers. The enthusiasm surrounding the latest technology...
New Scale Technologies commercially licenses technology, developed at the Allen Institute for Neural Dynamics, for next-generation multi-probe insertion system for acute in vivo electrophysiology recordings
The new Modular Insertion System (MIS) will enable positioning of up to 24 Neuropixels probes, along with microscope modules for visualization and laser modules for optogenetics. Victor, NY – The Allen Institute for Neural Dynamics has selected New Scale...Sending commands to Pathfinder from other applications
New Scale’s Multi-Probe Micromanipulator (MPM) System Pathfinder Software V2.8.2 includes an HTTP server that allows the MPM System to accept commands from third party applications. This can include Matlab scripts. For example, Dr. David Eriksson (Veit Lab,...
Neuropixels Trajectory Explorer and Pinpoint working with New Scale’s Pathfinder for the Multi-Probe Micromanipulator (MPM) System
Two open-source trajectory planning tools – Pinpoint (left) and Neuropixels Trajectory Explorer (right) – interface with New Scale’s Pathfinder software for neural probe positioning. The developers of the Neuropixels Trajectory Explorer and the...
Neural Probe with Integrated LEDs Advances in Vivo Opto-Electrophysiology
The NeuroLight Optoelectrode is a customizable electrode for applications including optogenetics where a microdrive, such as the MPM System from New Scale Technologies, is used for fine positioning. These optoelectrodes have recording sites and precisely defined µLEDs...Video: MPM Pathfinder & Neuropixels Trajectory Explorer
This short overview video shows how passing probe location coordinates from New Scale’s MPM Pathfinder software to the open-source Neuropixels Trajectory Explorer software allows researchers to see probe locations in the Allen Institute Common Coordinate...Webinar on Demand: MPM Pathfinder & Neuropixels Trajectory Explorer
Watch this on-demand webinar for a 1-hour demonstration, with question and answer session, about using Pathfinder and Neuropixels Trajectory Explorer, hosted by Ed Friedrich, Life Sciences Business Manager, New Scale Technologies, and Andrew Peters, developer of Neuropixels Trajectory Explorer and Principal Investigator, Peters Lab, University of Oxford Department of Physiology, Anatomy and Genetics.
Pathfinder V2.8 for MPM Neural Probe Manipulator System Released
Support for integration with open-source trajectory planning and data acquisition apps is the key feature in the latest release of New Scale MPM Pathfinder Software for the MPM Multi-Probe Micromanipulator (MPM) System. New Scale Technologies has announced general...
New Target Images for MPM System Setup
MPM System Setup screen has new target images (calibration blocks) for larger adult mouse and adult rat. The upcoming Pathfinder MPM Software V2.8.5 release for the Multi-Probe Micromanipulator (MPM) System includes two additional target images (also called...
Deisseroth Lab explores link between cardiac physiology and emotional states
Figure from the recent Deisseroth Lab article in Nature: d, Electrode tracks from n = 5 mice (3 ChRmine and 2 control) over 60 recording sessions co-registered to the common Allen Brain Atlas. e, Locations of recorded single units overlaid onto the Allen Brain Atlas....
Use gaming controllers with the MPM System
The upcoming Pathfinder software release for the Multi-Probe Micromanipulator (MPM) System contains a number of features and enhancements* suggested by our users. One such feature is support for Xbox-style gaming controllers (wired, or with Bluetooth or USB wireless...
MPM System supports research into cellular-level mechanisms underlying brain function
Researchers at the Deisseroth Lab at Stanford University use the MPM Multi-Probe Micromanipulator for in-vivo electrophysiology with optogenetic stimulation. They published results in an article, “Cell-type-specific population dynamics of diverse reward computations,”...
Allen Institute shares protocol for inserting multiple probes in awake, head-fixed mice
Allen Brain Observatory Neuropixels recording rig, from the paper in Nature Protocols. The label “f” indicates one of the six three-axis New Scale manipulators in the rig. As the creator and supplier of the Multi-Probe Manipulator System (MPM), we often are asked to...
Slow insertion of silicon probes improves neural recording quality
A paper provides convincing evidence for the benefits of inserting silicon probes slowly into the brain for acute neural recording. The New Scale MPM Multi-Probe Micromanipulator System enables slow, smooth, and fully programmable insertion speeds.
Big Science. Big Data. Big Discoveries.
NEUROSCIENCE 2022 WRAP-UP By David Henderson, CEO It was great to be in-person for Neuroscience 2022, and to see first-hand the amazing work being done by our partners and customers around the world. The MPM Micro-Manipulator System was shown at four booths: New Scale...
