Optogenetics has progressed rapidly from its beginnings in 2005, thanks in part to advances in supporting fields including photonics and micro-mechatronics. The MPM Micromanipulator is unique in its ability to simultaneously position multiple silicon probes and optical fibers for optogenetics.
An article in Nature Communications describes how researchers in Italy combined neural manipulations, resting-state fMRI and in vivo electrophysiology (using the New Scale MPM Multi-Probe Micromanipulator) to probe how inactivation of a cortical node causally affects brain-wide fMRI coupling in the mouse.
To achieve the goals of higher throughput and lower costs, NGS instrument developers are using smaller samples, parallel sequencing, and more automation. These factors necessitate miniaturization and distributed control of the photonics subsystems used in DNA sequencing instruments.