Multi-Probe Micromanipulator System

Multiple silicon probes. One simple micromanipulator system.

Maximize productivity and precision with automated probe positioning for acute in-vivo recording

Supports neural probes from Imec NeuroPixels, NeuroNexus, Cambridge Neurotech and more

The MPM Multi-Probe Micromanipulator System provides convenient, automated positioning of multiple neural probes for acute in-vivo recording in electrophysiology and optogenetic research.

Simple to set up and operate, it is the first micro-manipulator designed specifically for use with silicon probes.

The compact design allows for independent positioning of multiple probes in the smallest space, with ample clear area for a virtual task environment. Automatically and independently move each probe to the optimum location in the brain.

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VIRTUAL COORDINATE SYSTEM for Intuitive PC Control

The MPM Software’s Virtual Coordinate System (currently supported for inverted system configuration only) simplifies probe positioning. Enter the start and stop coordinates to register probe locations to a 2D image or a 3D reference space using stereotatic coordinates. The software automatically calculates all approach angles. Each probe moves independently within this global space, rather than along its local axes. This makes it much easier to position and keep track of multiple probe locations.

Use the simulation mode to plan and visualize probe positions and approach angles, then check for potential probe interference. You spend less time calculating angles and more time recording.

 All MPM Systems (both inverted and upright) include software that supports:

  • Control of up to eight probes in a single PC window. Open additional windows for additional probes.
  • Coarse, fine and insertion step modes
  • Display of absolute and configurable relative positions
  • Automated z-axis insertion – very slow with x/y movement disabled
  • Multiple editable configurations – step size, speed, axis associations, etc.
  • Optional joystick or other input device control (PC compatible USB-HID)

Compact, easy-to-use system

Manipulate multiple probes in the smallest space

A mounting ring allows multiple probe arm assemblies to be positioned around the target – from one probe to eight or more. In inverted configuration, the arms are mounted to the underside of an elevated platform, maximizing clear space below the probes for animal interaction with a virtual task environment. Alternatively, the arms can be mounted to standard laboratory tables with imperial or metric hole patterns.

Simple pre-adjustment

Each probe arm has four degrees of freedom for initial pre-adjustment. Use the displacement markings to register the location of each probe in stereotaxic coordinates and calculate the approach angle. Enter this information into the Virtual Coordinate System (VCS) software and remove real-time geometry puzzles from the time it takes to do a recording. Use the simulation mode for a 3D visualization of probe assemblies, along with target bregma and lambda locations, to plan probe positions or practice moving. Email us for the VCS Software Overview Guide.

Precise motorized positioning

Each probe arm also has three axes of motorized motion for automated positioning. The motorized positioners allow precise control of x-y location and z insertion depth, automatically and independently moving each probe to the optimum location in the brain. The standard motorized positioners offer 15 mm of travel on each axis, with high force and stiffness. Learn more about the M3-LS micro stages.

The New Scale MPM System automatically and independently positions multiple silicon probes for stable acute in-vivo research including electrophysiology and optogenetics.

Designed for Silicon Probes

imec Neuropixels – NeuroNexus – Cambridge Neurotech

The MPM System is the first micromanipulator specifically designed for silicon probes. It is also compatible with tetrodes and other probes. It can be used to simultaneously position optical waveguides or optical fibers for research combining electrophysiology with optogenetic stimulation.

Probe mounting kits are available for many commercially available probes including Neuropixels 1.0 probes with silcon or metal cap. We also offer custom probe mount design.

Protect your probes

A steel reference probe reduces setup time and minimizes risk of damage to probes during setup. Repeatable stops allow you to simply swing the probe arm up to replace the reference probe with a silicon probe, and return it to the target position.

A tech note describes the probe mounting and pre-positioning solution for the NeuroNexus A32 probe with NeuroNexus OM32 adapter. Other adapters use a similar pre-positioning technique.

Advantages

  • Compact size: Independently position mulitple probes in the smallest space
  • Fast set-up: Fully engineered, modular apparatus space-optimized for upright or inverted experiments
  • Easy operation: 24 axes of automated motion controlled using a single PC window (open additional windows for more probes)
  • Automated sub-micrometer probe adjustments with absolute position measurement and control
  • Gross manual + fine automated control in one system
    • Four-axis manual pre-positioning with repeatable stops
    • Three-axis motorized fine positioning with 15 mm travel on each axis

Configurable to your experiment

MPM Systems are fully configurable for number of probe arms, inverted or upright position, and type of probe holders. Each system is complete and easy to assemble with the tools and hardware provided. All cables and connectors are labeled including standard USB cables to the PC. The MPM software installs on your Windows PC in minutes.

Resources

Download user guides and software for your Multi-Probe Micromanipulator (MPM) System. Watch How-To videos on system setup and operation.  (User account creation required)

News

Neuropixels 1.0 probes are supported by the MPM System. A probe holder for the ultra-high density Neuropixels probe from imec is available for order now.

Where To Buy

Sales and support for the Multi-Probe Micromanipulator (MPM) System is provided by our worldwide partners with experience in neuroscience and advanced research instrumentation.